22254-24-6 8-Isopropylatropinium bromide

Ipratropium bromide ni a tun mọ ni Haizhupanidine, isopropyl atropine, isopropyl scopolamine, isopropyl atropine, ipratropine bromide, isopropyl atropine bromide, ipratropine bromide, ipratropium bromide, ati ipratropium bromide.O ti wa ni a funfun crystalline lulú pẹlu kikorò lenu.Ojuami yo 232℃-233℃.Tiotuka ninu omi, die-die tiotuka ni ethanol, insoluble ni miiran Organic solvents.Orukọ kemikali: Brominated α- (hydroxymethyl) -phenylacetic acid - 8-methyl-8-isopropyl - azocyclic [3,2,1] -3-octyl ester.O jẹ oogun anticholinergic, eyiti o ni ipa isinmi ti o lagbara lori iṣan didan ti bronki ati ipa antiasthmatic lori arun aarun obstructive ẹdọforo onibaje.Ipa rẹ jẹ kedere, ipa iyara ati ipari gigun.Ipratropium bromide tun n ṣakoso yomijade ti awọn keekeke ti mucus ati mu ilọsiwaju ciliary ṣiṣẹ, nitorinaa dinku idena sputum lati mu isunmi dara sii.Nibayi, idinku ti sputum tun dinku bronchospasm ti o ṣẹlẹ nipasẹ irritation bronchial.Fun idena ati itọju ikọ-fèé ikọ-fèé ati anmitis onibaje ikọ-fèé, ni pataki fun awọn alaisan ti ko le farada lilo β-agonist iṣan iṣan, tachycardia.Ọja yii le ṣee lo ni apapo pẹlu awọn agonists beta lati mu ipa ti ara wọn pọ si, gẹgẹbi ni apapo pẹlu finoterol lati ṣe aerosol (BERODU - AL) fun ikọ-fèé, bronchitis onibaje ati emphysema.Ti a bawe pẹlu β-adrenergic receptor stimulants (fun apẹẹrẹ, efinifirini isopropyl), ọja yii ko ni awọn ipa ẹgbẹ inu ọkan ati ẹjẹ, ati ni afiwe pẹlu β2-receptor stimulants (fun apẹẹrẹ, Suquanling), ọja yii ni ipa ilana ti o lagbara sii lori iwọn didun phlegm.
Sokiri ifasimu.40 ~ 80μg lẹẹkan, 2 ~ 4 igba ọjọ kan.Nigbati o ba nlo, akọkọ yọ ideri ikarahun ideri kuro, fi oju ikarahun ideri si ori nozzle, yi igo naa si isalẹ, ni ikarahun ideri ni ẹnu, ṣe ifọkansi ọfun, fa gaasi ni akoko kanna, tẹ nozzle naa. lori àtọwọdá, fa omi naa simu, di ẹmi rẹ mu fun iṣẹju kan.Tun imolara loke ni ẹẹkan ti o ba jẹ dandan.Aerosol: 0.025% ojutu.Tabulẹti: 10mg/tabulẹti.
Majele anticholinergic to lagbara le ṣe itọju pẹlu awọn inhibitors cholinesterase.
Awọn aati ikolu ti ipratropium bromide jẹ iru si atropine, eyiti o le fa palpitation, orififo, dizziness, aifọkanbalẹ, ríru, ìgbagbogbo, irora nipa ikun, iwariri, iran ti ko dara, ẹnu gbigbẹ, Ikọaláìdúró, dysuria, aggravation ti awọn ami atẹgun ati sisu.
Ipratropium bromide jẹ antagonist muscarinic, bronchodilator, ati iyọ isopropyl ti AtropineN.
Ipratropiumbromide ati Formoterol ni idapo ni apakan lati daabobo ẹdọforo lati iredodo onibaje ati tobi awọn ẹdọforo, idinku awọn neutrophils nipasẹ didi iṣẹ ṣiṣe nipasẹ MMP-9.Ipratropiumbromide (1nM) ṣe pataki pọ si kalisiomu bromide, dinku pipinka siwaju ati pọ si annexin-V abuda.Lẹhin itọju Ipratropiumbromide, hemolysis pọ si diẹ ṣugbọn pataki.Ipratropiumbromide fa iku iku ẹjẹ pupa tabi eryptosis, nipataki nitori imudara kalisiomu.
Ipratropium gbẹ lulú inhalation (DPI) jẹ bronchodilator ti o munadoko ninu awọn ẹṣin isinmi ni iwọn lilo 2400 mg / ẹṣin, pẹlu ipa diẹ lori caliber oke atẹgun nigba imularada.Ninu awọn eku ti cadmium ti a tọju, Ipratropium ṣe pataki idinku ninu sisan sẹẹli iredodo parenchymal ati akiyesi awọn ọgbẹ ẹdọfóró ti o ni ibatan pọpọ.Ipratropium ni apakan kan ṣe aabo awọn ẹdọforo lati iredodo nipasẹ didin infiltration neutrophil.Ni guinea pig tracheal dan isan, Ipratropium jẹ antagonist ti o ṣe idiwọ olugba muscarinic inhibitory prebound ti nafu parasympathetic ẹdọfóró.Ipratropium tun ti han lati jẹ antagonist ti o lagbara lẹhin-abuda si awọn olugba inhibitory muscarinic.Ipratropium dinku awọn iyipada ti o pọju ninu titẹ àyà ati pe o pọ si ibamu agbara (Cdyn) ni isunmi tidal (Pplmax afikun) ati resistance ẹdọforo (RL) ninu awọn ẹṣin.