China 67630-00-6 Tert-butoxycarbonyl-4-NO2-phenylalanine-ethyl ester Olupese ati Factory |Jiayinglai

67630-00-6 Tert-butoxycarbonyl-4-NO2-phenylalanine-ethyl ester

Apejuwe kukuru:

Ifarahan	Funfun si Paa-White kirisita tabi kirisita lulú.
MF	C16H22N2O6
MW	338.36
Mimo	98+

Fi imeeli ranṣẹ si wa

Alaye ọja

Ipo gbigbe&ọna gbigbe ti a ṣeduro:
nipasẹ afẹfẹ, nipasẹ okun tabi nipasẹ kiakia

Ipo ipamọ:
Ti di ni gbigbẹ, Iwọn otutu yara

Ibere ti o kere ju Qty:
Idunadura

Ijẹrisi:
COA, HPLC, GC, HNMR, Assay, Omi Akoonu(KF), TLC wa

Awọn itumọ ọrọ sisọ

(S) -ethyl 2- (tert-butoxycarbonylaMino) -3- (4-nitrophenyl) propanoate;
Boc-(4-NO2)-L-Phe-OEt;
Boc-(4-NO2) -Oet;
Boc-Phe (4-NO2) -Oet;
L-Phenylalanine;
N-[(1,1-dimethylethoxy) carbon]-4-nitro-, ethyl ester

akojọpọ Iṣakojọpọ

Wọn ti wa ni maa lo lati lowo etu.Ati pe wọn le ṣe idiwọ oorun ati omi lati di buburu.

lode packing

Paali lile le daabobo awọn ọja rẹ lati jamba ati jijẹ tutu.

Awọn ohun elo

Nidanib, kemikali ni.Orukọ kemikali 1 h - indole - 6 - carboxylic acid, 2, 3 - dihydro - 3 - [[4 - (methyl [(4 - methyl - 1 - piperazine) acetyl] amino] phenyl] amino] benzene heartland ti methyl] - 2 - oxygen -, methyl ester, (z) - isẹgun, ọja yi ti lo lati toju idiopathic ẹdọforo fibrosis (IPF).
Nidanib ti ṣe iwadi awọn alaisan 1,529 pẹlu idiopathic pulmonary fibrosis (IPF) ni awọn idanwo ile-iwosan pupọ.Awọn data ailewu ti a gbekalẹ da lori lafiwe ti awọn alaisan 1061 ti a fun nidanib 150 miligiramu lẹmeji lojoojumọ ati placebo ni ipele 52-ọsẹ meji 3, laileto, afọju-meji, awọn iwadii iṣakoso ibibo (INPULSIS-1 ati INPULSIS-2).Awọn iṣẹlẹ ikolu ti o wọpọ julọ ti o ni nkan ṣe pẹlu lilo nidanib pẹlu gbuuru, ríru ati ìgbagbogbo, irora inu, isonu ti ounjẹ, pipadanu iwuwo, ati awọn enzymu ẹdọ ti o ga.Jọwọ tọka si [Awọn iṣọra] fun iṣakoso awọn aati ikolu ti o baamu.Isọri Ẹran ara eleto (SOC) ti MedDRA n pese akopọ ti awọn aati ikolu ati ipinya igbohunsafẹfẹ.
Nidanib jẹ sobusitireti fun P-gp (wo Pharmacokinetics).Ninu iwadi kan pato ti awọn ibaraenisepo oogun, iṣakoso apapọ ti ketoconazole, inhibitor P-gp ti o lagbara, ifihan ti o pọ si nidanib si awọn akoko 1.61 nipasẹ agbegbe labẹ ọna (AUC) ati awọn akoko 1.83 nipasẹ ifọkansi ti o ga julọ (Cmax).
Ninu iwadi ibaraenisepo oogun pẹlu P-gp inducer rifampicin ti o lagbara, ifihan si nidanib dinku si 50.3%, bi a ṣe wọn nipasẹ agbegbe ti o wa labẹ ọna (AUC), nigba ti a ba ni idapo pẹlu rifampicin ni akawe pẹlu Nidanib nikan.Nipa ifọkansi ti o ga julọ (Cmax), o dinku si 60.3%.
Nigbati a ba nṣakoso ni apapo pẹlu ọja yii, awọn inhibitors P-gp ti o lagbara (fun apẹẹrẹ, ketoconazole tabi erythromycin) le ṣe alekun ifihan si nidanib.Ni awọn iṣẹlẹ wọnyi, ifarada alaisan si nidanib yẹ ki o ṣe abojuto ni pẹkipẹki.Ṣiṣakoso awọn aati ikolu le nilo idaduro, idinku iwọn lilo, tabi dawọ itọju pẹlu ọja yii (wo [Lilo ati iwọn lilo]).
Awọn oludasilẹ agbara P-gp (fun apẹẹrẹ, rifampicin, carbamazepine, phenytoin ati St. John's wort) le dinku ifihan si nidanib.Awọn akojọpọ omiiran pẹlu ko si tabi idinku P-gp fifa irọbi yẹ ki o gbero.

jẹmọ awọn ọja

Gly-Phe	Boc-Phe-Gly-Ome	HN-Me-L-Phe.Hcl	Boc-D-Phe-D-Phe
Boc-D-4-Chloropheny(alanine)	Fmoc-L-Phe-OH	L-Phe-NH2.Hcl	Boc-Phe-Gly
L-Ala-Phe-OH	Fmoc-D-Phe-OH	4-NO2-Phe-Oet	Boc-L-Phe-Onp
Boc-Ala-Phe-OH	Fmoc-N-Me-L-Phe-OH	4-NO2-Phe-Oet.HCl	Boc-L-Phe-Oet
Boc-Ala-Phe-OH	FMOC-N-Me-D-Phe-OH	HD-Phe-OMe·HCl	Boc-4-NO2-D-Phe-OEt
Fmoc-β-Ala-D-phe	Fmoc-Phe-Cl	HL-Phe-OMe.HCl	Boc-D,L-Phe(4-NO2)-OH
Leu-Phe.Hcl	Fmoc-Phe (4-NO2)-OH	H-DL-Phe-OBzl .tos	Fmoc-Phe-Phe-OH
Boc-Leu-Phe	Cbz-L-Phe-OH	H-DL-Phe(4-NO2)-OH.H2O	Fmoc-Phe-Gly-OH
Cbz-L-Phe-Leu-OH	Cbz-D-Phe-OH	HL-Phe-OBzl.HCl	Fmoc-D-Phe (4-NO2)-OH
L-Phe	Cbz-DL-Phe-OH	HL-Phe-OEt.HCl	Cbz-Phe-Arg-OH
HD-Phe-OH	Cbz-D-Phe-OL	L-Phe-NH2	Cbz-Phe-Ala-OH
L-Phe-NCA	ZN-Me-L-Phe-OH	D-Phe-NH2	Cbz-Phe-Gly-OH
Tos-Phe	cbz-L-Phe-OSU	N-Ac-L-Phe-OH	Cbz-Phe-Met-OH
L-Phe-ol	Phe-Ala	N-AC-L-Phe-Ome	Cbz-Phe-Gly-Oet
L-Phe (4-NO2) -OH	L-Phe-Phe	N-Pht-Phe-OH	Boc-Phe-Gly-Gly-OH
L-Phe (4-NO2) .H2O	L-Phe-Trp	Boc-Phe-OH	Fmoc-L-Thr (tBu) -Phe-OH
D-Phe (4-NO2)-OH.h2o	L-Phe-Leu-OH	Boc-D-Phe-OH	D-Phe-NH2
D-Phe (4-NO2)-OH	L-Phe-Tyr-OH	Boc-DL-Phe-OH	Tir-Phe
N-Me-D-Phe	L-Phe-Gly	BOC-N-Me-D-Phe-OH	DL-Phe-Ome.Hcl
HN-Me-L-Phe-OH	D-Phe-D-Phe	Boc-N-Me-DL-Phe-OH	Boc-Met-Leu-Phe
L-Phe.hcl	L-Phe-OBzl-OH	Boc-N-Me-L-Phe-OH	Asp-Phe-Ome
4-NO2-D-phe.hcl	D-Phe-Obzl.Tos	Boc-N-Me-L-Phe-OH.DCHA	L-Homophe-OH
HL-Phe-OtBu.HCl	Boc-Phe-Ala-OH	Boc-DN-Me-Phe•DCHA	D-Homophe-OH
HD-Phe-OtBu.HCl	Boc-Phe-Leu-OH	Boc-Phe-Ol	L-Homophe-Oet.Hcl
D, L-Phe-OtBu HCl	Boc-Phe-Trp-OH	Boc-D-Phe-Ol	D-Homophe-Oet.HCl
HD-Phe (4-NO2)-Ome.HCl	Boc-L-Phe-Tyr-OH	Boc-Phe-NH2	Boc-L-Homophe-OH
D-Phe-Obzl.Hcl	Boc-Phe-Phe-OH	Boc-L-Phe-Ome	Boc-D-Homophe-OH
DL-Phe-Ome.Hcl	Boc-D-Phe-Phe	Boc-D-Phe-Ome	Fmoc-L-HomoPhe-OH
Boc-D-Phe (4-NO2)-OH	Cbz-D-Homophe-OH	Boc-Phe-Obzl	Fmoc-D-Homophe-OH
Boc-L-Phe-OSU	Boc-Homophe-Leu-Phe-Ome	Boc-4-NO2-Phe-OH	Cbz-L-Homophe-OH
Boc-D-Phe-OSU

Iwaju

1. R&D iṣẹ wa
2. ISO ifọwọsi olupese, didara lopolopo
3.A ni kikun ilana ti iṣẹ atẹle lakoko iṣelọpọ
4.High iye owo to munadoko
Awọn iwe-ẹri 5.Quality ti a pese fun ibeere alabara
6.Great lẹhin-tita iṣẹ, mimu sunmọ ibasepo pẹlu onibara
7.Full awọn oluşewadi lati ṣe iranlọwọ lati dinku awọn idiyele gbigbe
8.Free ayẹwo ti a nṣe lati ṣayẹwo didara ṣaaju si eyikeyi sisanwo
9.Payment igba idunadura
Awọn alabara 10.Assit ṣe pẹlu awọn ọran ni Ilu China