China 200124-22-7 Tert-butoxycarbonyl-arginine (Pbf) -OH Olupese ati Factory |Jiayinglai

200124-22-7 Tert-butoxycarbonyl-arginine(Pbf)-OH

Apejuwe kukuru:

Ifarahan	Funfun si Paa-White kirisita tabi kirisita lulú.
MF	C24H38N4O7S
MW	526.65
Mimo	98+

Fi imeeli ranṣẹ si wa

Alaye ọja

Ipo gbigbe&ọna gbigbe ti a ṣeduro:
nipasẹ afẹfẹ, nipasẹ okun tabi nipasẹ kiakia

Ipo ipamọ:
Ti di ninu gbigbẹ, fipamọ sinu firisa, labẹ -20 ° C

Ibere ti o kere ju Qty:
Idunadura

Ijẹrisi:
COA, HPLC, GC, HNMR, Assay, Omi Akoonu(KF), TLC wa

Awọn itumọ ọrọ sisọ

N5-[[(2,3-Dihydro-2,2,4,6,7-pentamethylbenzofuran-5-yl) sulfonyl] amino] iminomethyl] -N2-BOC-L-ornithine;
Nα-Boc-Nω- (2,2,4,6,7-pentamethyldihydrobenzofuran-5-sufonyl) -L-arginine;
Nalpha-Boc-Nomega- (2,2,4,6,7-pentamethyl-2,3-dihydrobenzo [b]furan-5-sulfonyl) -L-arginine;
BOC-ARGININE(PBF) -OH;BOC-L-ARG(PBF) -OH;
BOC-N-OMEGA-(2,2,4,6,7-PENTAMETHYLDIHYDROBENZOFURAN-5-SULFONYL)-L-ARGININE

akojọpọ Iṣakojọpọ

Wọn ti wa ni maa lo lati lowo etu.Ati pe wọn le ṣe idiwọ oorun ati omi lati di buburu.

lode packing

Paali lile le daabobo awọn ọja rẹ lati jamba ati jijẹ tutu.

Awọn ohun elo

Boc-Arg (Pbf) -OH jẹ itọsẹ arginine.
Bivalirudine, anticoagulant sintetiki ti o jẹ ibatan ibatan 20-peptide ti hirudin, ni a fọwọsi fun tita ni Amẹrika ni ọdun 2000. Abẹrẹ naa jẹ funfun, nkan alaimuṣinṣin tabi amorphous.Bivarudine le sopọ ni pato si aaye katalitiki thrombin ati aaye itagbangba itagbangba anion, ati pe o ṣe idiwọ iṣẹ ṣiṣe ti thrombin taara, nitorinaa ṣe idiwọ ifasilẹ ti itọsi ati fa nipasẹ thrombin, ati pe ipa rẹ jẹ iyipada.Bivarudine jẹ lilo akọkọ bi apakokoro fun idasi iṣọn-alọ ọkan ti o yan (PCI) ninu awọn agbalagba.
Bivarudine jẹ oludena taara ti thrombin, eyiti o sopọ ni pataki si awọn aaye katalitiki ati awọn aaye ifunmọ exo anion ti thrombin ọfẹ ati lori thrombus.Ilana abuda laarin bivaludine ati thrombin jẹ iyipada, ati thrombin le ṣe atunṣe iṣẹ-ṣiṣe ti ẹda atilẹba ti thrombin nipasẹ enzymolysis laiyara ti asopọ peptide laarin bivaludine Arg3-Pro4.
Awọn ijinlẹ in vitro ti fihan pe bivarudine ko le ṣe idiwọ thrombin ọfẹ ti ita nikan, ṣugbọn tun ṣe idiwọ isọpọ thrombin pẹlu awọn didi ẹjẹ laisi didoju nipasẹ awọn nkan ti a tu silẹ nipasẹ awọn platelets.O le fa akoko prothrombin apakan (APTT), akoko thrombin (TT), akoko prothrombin (PT) ati akoko coagulation ti nṣiṣe lọwọ (ACT) ti mu ṣiṣẹ nipasẹ pilasima deede.Ibasepo laini wa pẹlu ifọkansi ti bivarudine, ṣugbọn boya ibamu yii wa ninu ohun elo ile-iwosan ko ṣe akiyesi.
O ti royin ninu awọn iwe-kikọ pe awọn oogun elegbogi ti awọn alaisan ti o ngba angioplasty iṣọn-alọ ọkan (PTCA) jẹ laini laini lẹhin iṣakoso iṣọn-ẹjẹ ti bivarudine.A fun alaisan naa ni 1 mg / kg ni iṣọn-ẹjẹ bi iwọn iwọn fifuye, lẹhinna idapo IV miiran ti 2.5 mg / kg / hr fun awọn wakati 4, eyiti o duro ni 12.3 ± 1.7 mg / ml ni vivo.Bivarudine jẹ imukuro lati pilasima nipasẹ hydrolysis kidirin ati ibajẹ protease.Iyọkuro idaji-aye ti awọn alaisan ti o ni iṣẹ kidirin deede jẹ nipa iṣẹju 25, ati imukuro idaji-aye ti awọn alaisan ti o ni iwọntunwọnsi ati ailagbara kidirin ti o lagbara ti gbooro sii.O fẹrẹ to 25% ti bivarudine le yọkuro nipasẹ iṣọn-ọgbẹ ati yọkuro nipasẹ hemodialysis.ACT yẹ ki o ṣe abojuto ni awọn alaisan ti o ni ailagbara kidirin.Ninu awọn oluyọọda ti ilera, ipa anticoagulant ni a ṣe akiyesi lẹsẹkẹsẹ lẹhin iṣakoso iṣọn-ẹjẹ ti bivarudine, pẹlu PT gigun, ACT ati APTT.Ọkan si wakati meji lẹhin yiyọkuro, ACT pada si ipele iṣakoso iṣaaju.

jẹmọ awọn ọja

Cbz-Phe-Arg-OH	Boc-L-Arg-OH.HCl
Arg-Tyr-Oet	Boc-L-Arg-OH.HCl.H2O
HL-Arg-OH	Boc-D-Arg-OH•HCl•H2O
HD-Arg-OH	Boc-Arg (Cbz) -OH
DL-Arg-OH	Fmoc-L-Arg-OH
L-Arg-Ome.2Hcl	Fmoc-D-Arg-OH
D-Arg-Ome.2HCl	Fmoc-L-Arg (NO2)-OH
L-Arg (Pbf) -OH	Fmoc-L-Arg (Pbf) -OH
D-Arg (NO2)-OH / N-NO2-D-Arg	Fmoc-HoArg (Pbf) -OH
HL-Arg (NO2)-OH	Fmoc-Arg (Tos) -OH
HL-Arg (Tos) -OH	Fmoc-D-Arg (Tos) -OH
L-Arg-NH2	Fmoc-D-Arg (Pbf) -OH
Boc-L-Arg-OH	Cbz-Arg-OH
Boc-D-Arg(Pbf)	Cbz-D-Arg-OH
Boc-Arg-Oet	Cbz-L-Arg (Pbf) -OH
Boc-L-Arg-Ome	Cbz-D-Arg (pbf) .CHA
Boc-L-Arg (Tos) -OH	Cbz-D-Arg-Gly-OH
Boc-L-Arg (NO2)-OH	L-Arg (Pbf) -Asp
Fmoc-L-HomoArg-OH	L-Homoarg.hcl

Iwaju

1. R&D iṣẹ wa
2. ISO ifọwọsi olupese, didara lopolopo
3.A ni kikun ilana ti iṣẹ atẹle lakoko iṣelọpọ
4.High iye owo to munadoko
Awọn iwe-ẹri 5.Quality ti a pese fun ibeere alabara
6.Great lẹhin-tita iṣẹ, mimu sunmọ ibasepo pẹlu onibara
7.Full awọn oluşewadi lati ṣe iranlọwọ lati dinku awọn idiyele gbigbe
8.Free ayẹwo ti a nṣe lati ṣayẹwo didara ṣaaju si eyikeyi sisanwo
9.Payment igba idunadura
Awọn alabara 10.Assit ṣe pẹlu awọn ọran ni Ilu China